The Palazzo has a facade that denounces interventions from various periods up to the arrangement desired by Onorato Zizzi in the Renaissance period. The solutions of the oldest medieval building are still visible with lunate arches, single lancet windows and a roof that was later raised.
The Renaissance adaptation is evident above all in the monumental portal framed in a classical style entablature. The large arched archway opens between two fluted columns resting on large bases. At the top, the entablature breaks in correspondence with the capitals of the columns. On the front of the same entablature, two clip-on heads, representing the symbols of the city of Bari, Japige and Barione, are located on the sides of the aforementioned inscription.
The historical events of this building are intertwined with those of its owner and client Onorato Zizzi. He was one of the most contradictory characters in the court of Queen Bona Sforza. Court doctor following accusations deriving from the jealousy of some court gentlemen he was imprisoned, when his palace was still to be completed. It was for this reason that he decided to affix the famous inscription 'Post tenebras spero lucem'. A wish for the recognition of his innocence and the hope of being able to live in his sumptuous home.
On the arch of the portal, enclosed in a visibly blackened square frame, there are also two stone medallions depicting the two founders of the city: Iapige and Barione